Evaluation of risk of nephrotoxicity with high dose, extended-interval colistin administration
نویسندگان
چکیده
منابع مشابه
Evaluation of Risk Factors for Intravenous Colistin Use-related Nephrotoxicity.
OBJECTIVES We investigated the incidence of and risk factors for nephrotoxicity in patients using intravenous colistin. METHODS This retrospective, observational study was conducted at Karadeniz Technical University, Faculty of Medicine, clinics and intensive care unit between 1 January 2009 and 1 January 2013. Intravenous colistin was administered to 133 patients at a dose of 2.5-5.0 mg/kg/d...
متن کاملHigh-Dose, Extended-Interval Colistin Administration in Critically Ill Patients: Is This the Right Dosing Strategy? A Preliminary Study
BACKGROUND Gram-negative bacteria susceptible only to colistin (COS) are emerging causes of severe nosocomial infections, reviving interest in the use of colistin. However, consensus on the most effective way to administer colistin has not yet been reached. METHODS All patients who had sepsis due to COS gram-negative bacteria or minimally susceptible gram-negative bacteria and received intrav...
متن کاملNephrotoxicity of high and conventional dosing regimens of colistin: A randomized clinical trial
BACKGROUND: Nephrotoxicity has been a major long-standing concern about colistin. This study was designed to compare nephrotoxicity of high dose and conventional dose of colistin. METHODS: A randomized open-labeled clinical trial on 40 patients with multi-drug resistant gram negative infections was designed. Patients were allocated into two equal-size groups receiving high and conventional dose...
متن کاملNephrotoxicity of high and conventional dosing regimens of colistin: A randomized clinical trial
BACKGROUND: Nephrotoxicity has been a major long-standing concern about colistin. This study was designed to compare nephrotoxicity of high dose and conventional dose of colistin. METHODS: A randomized open-labeled clinical trial on 40 patients with multi-drug resistant gram negative infections was designed. Patients were allocated into two equal-size groups receiving high and conventional dose...
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ژورنال
عنوان ژورنال: Indian Journal of Critical Care Medicine
سال: 2014
ISSN: 0972-5229,1998-359X
DOI: 10.4103/0972-5229.136070